A Novel Model of Perifascial Areolar Tissue Transplant in Rats

Autor: Junya Oshima, Kaoru Sasaki, Yoichiro Shibuya, Mitsuru Sekido
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Indian Journal of Plastic Surgery, Vol 55, Iss 03, Pp 268-271 (2022)
Druh dokumentu: article
ISSN: 0970-0358
1998-376X
DOI: 10.1055/s-0042-1756130
Popis: Background Perifascial areolar tissue (PAT) transplant is a method of transplanting loose connective tissue harvested in a sheet form from above the fascia to the wound bed and is effective for wounds with exposed ischemic tissue. However, the engraftment mechanism is unknown, and no animal models of PAT transplant for wound healing exist. Methods In this study, we harvested connective tissue from the backs of Wistar rats in a sheet form to simulate a human PAT transplant. The PAT was affixed to exposed bone of the head. Results In the PAT(+) group, the wound areas gradually decreased due to epithelialization and contraction. The wound area of the PAT(+) group was significantly smaller than that of the PAT(−) group. Conclusions This clinically relevant rat model is useful for elucidating the mechanism of the PAT transplant and establishing a reliable surgical method.
Databáze: Directory of Open Access Journals
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