Anti-inflammatory effects of 4′-demethylnobiletin, a major metabolite of nobiletin
Autor: | Xian Wu, Mingyue Song, Kanyasiri Rakariyatham, Jinkai Zheng, Shanshan Guo, Zhonghai Tang, Shuangde Zhou, Hang Xiao |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Journal of Functional Foods, Vol 19, Iss , Pp 278-287 (2015) |
Druh dokumentu: | article |
ISSN: | 1756-4646 43633897 |
DOI: | 10.1016/j.jff.2015.09.035 |
Popis: | Nobiletin, a citrus flavonoid, has been associated with various beneficial biological activities. 4′-Demethylnobiletin (4DN) is a major metabolite of nobiletin, and its tissue level was found to be much higher than that of nobiletin after oral administration of nobiletin in mice. Anti-inflammatory effects of 4DN were studied in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. The results showed 4DN not only dose-dependently inhibited LPS-induced nitric oxide production, but also significantly reduced expression of pro-inflammatory mediators, namely PGE2, IL-1β and IL-6. 4DN potently suppressed the expression of iNOS and COX-2 at both protein and mRNA levels. 4DN also inhibited nuclear translocation of NF-κB and AP-1. Furthermore, we demonstrated that 4DN activated transcription factor Nrf2 and its dependent genes including HO-1 and NQO1 whose expression may contribute to anti-inflammatory effects. The results demonstrated anti-inflammatory effects of 4DN and provided a scientific basis for using nobiletin as a nutraceutical to inhibit inflammation-driven diseases. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |