One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
| Autor: | B. Siva Kumar, Y. Haranadha Reddy, C. Radha Rani, G. Chnadra Sekhar Reddy |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | E-Journal of Chemistry, Vol 8, Iss S1, Pp S137-S142 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0973-4945 2090-9810 |
| DOI: | 10.1155/2011/906320 |
| Popis: | α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity. |
| Databáze: | Directory of Open Access Journals |
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