Homologous or Heterologous COVID-19 Booster Regimens Significantly Impact Sero-Neutralization of SARS-CoV-2 Virus and Its Variants
| Autor: | Rome Buathong, Taweewun Hunsawong, Supaporn Wacharapluesadee, Suriya Guharat, Ratthapat Jirapipatt, Sasiprapa Ninwattana, Nattakarn Thippamom, Anusara Jitsatja, Anthony R. Jones, Kamonthip Rungrojchareonkit, Jindarat Lohachanakul, Rungarun Suthangkornkul, Kedsara Tayong, Chonticha Klungthong, Stefan Fernandez, Opass Putcharoen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Vaccines, Vol 10, Iss 8, p 1321 (2022) |
| Druh dokumentu: | article |
| ISSN: | 10081321 2076-393X |
| DOI: | 10.3390/vaccines10081321 |
| Popis: | We determined the levels of neutralizing antibodies against the SARS-CoV-2 ancestral strain, Delta and Omicron variants of concern (VOCs), in 125 healthcare workers who received CoronaVac as their primary vaccination and later received either a single ChAdOx1 or a combi-nation of two consecutive boosters using either two ChAdOx1 doses or a ChAdOx1 or BNT162b2 as the primary and second boosters, respectively, or two doses of BNT162b2. The titers 12 weeks after primary vaccination were inadequate to neutralize all strains. After a single ChAdOx1 booster, the levels of neutralization at Day 30 varied significantly, with only a small proportion of participants developing neutralizing titers against Omicron at Day 7 and 30. The two doses of ChAdOx1 as the booster induced the lowest activity. A combination ChAdOx1 and BNT162b2 induced greater neutralization than by two doses of ChAdOx1. Two doses of BNT162b2 as the booster had the maximal activity against Omicron VOC. |
| Databáze: | Directory of Open Access Journals |
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