The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain
| Autor: | Simić Ivan, Irić-Ćupić Violeta, Vučić Rada, Petrović Marina, Mladenović Violeta, Veselinović Mirjana, Ignjatović Vladimir, Vučković Jelena |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Archives of Biological Sciences, Vol 66, Iss 3, Pp 1075-1081 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0354-4664 1821-4339 |
| DOI: | 10.2298/ABS1403075S |
| Popis: | The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain. |
| Databáze: | Directory of Open Access Journals |
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