Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem (M-SHIME)

Autor: Pilar Truchado, Emma Hernandez-Sanabria, Bouke N. Salden, Pieter Van den Abbeele, Ramiro Vilchez-Vargas, Ruy Jauregui, Dietmar H. Pieper, Sam Possemiers, Tom Van de Wiele
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Functional Foods, Vol 32, Iss , Pp 226-237 (2017)
Druh dokumentu: article
ISSN: 1756-4646
69943753
DOI: 10.1016/j.jff.2017.02.004
Popis: Prebiotic compounds aim at improving human health by targeting beneficial gut microbes. We used a dynamic in vitro model of the human digestive tract (M-SHIME®) to study the modulatory effects of long-chain arabinoxylans (LC-AX) towards luminal and mucosal microbiota. Two doses (3 and 6 g/L) of LC-AX were supplied to the proximal colon compartments of the M-SHIME, three times per day for 3 days. Next generation sequencing and multivariate statistical analysis revealed the distribution of key microbial genera across M-SHIME compartments. Supplementation of 6 g/L of LC-AX significantly increased the relative abundance of Bifidobacterium in both lumen (from 0.34% to 0.41%, 1.2-fold) and mucus (from 0.14% to 0.29%, 2.1-fold) compared with the control (P
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