Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem (M-SHIME)
Autor: | Pilar Truchado, Emma Hernandez-Sanabria, Bouke N. Salden, Pieter Van den Abbeele, Ramiro Vilchez-Vargas, Ruy Jauregui, Dietmar H. Pieper, Sam Possemiers, Tom Van de Wiele |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: | |
Zdroj: | Journal of Functional Foods, Vol 32, Iss , Pp 226-237 (2017) |
Druh dokumentu: | article |
ISSN: | 1756-4646 69943753 |
DOI: | 10.1016/j.jff.2017.02.004 |
Popis: | Prebiotic compounds aim at improving human health by targeting beneficial gut microbes. We used a dynamic in vitro model of the human digestive tract (M-SHIME®) to study the modulatory effects of long-chain arabinoxylans (LC-AX) towards luminal and mucosal microbiota. Two doses (3 and 6 g/L) of LC-AX were supplied to the proximal colon compartments of the M-SHIME, three times per day for 3 days. Next generation sequencing and multivariate statistical analysis revealed the distribution of key microbial genera across M-SHIME compartments. Supplementation of 6 g/L of LC-AX significantly increased the relative abundance of Bifidobacterium in both lumen (from 0.34% to 0.41%, 1.2-fold) and mucus (from 0.14% to 0.29%, 2.1-fold) compared with the control (P |
Databáze: | Directory of Open Access Journals |
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