Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

Autor: Eman A. Baraka, Mona G. Balata, Shereen H. Ahmed, Afaf F. Khamis, Enas A. Elattar
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Egyptian Rheumatology and Rehabilitation, Vol 48, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1110-161X
2090-3235
DOI: 10.1186/s43166-021-00065-2
Popis: Abstract Background This study aimed to measure the serum and synovial interleukin (IL)-37 levels in rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and healthy controls and to detect its relation to RA disease activity. Results This cross-sectional study included 50 RA patients with a mean age of 40.24 ± 8.62 years, 50 patients with PKOA with a mean age of 56.69 ± 4.21, and 40 healthy controls with a mean age of 41.75 ± 7.38 years. The mean serum IL-37 level in the RA patients (382.6 ± 73.97 pg/ml) was statistically significantly (P 0.94). Both serum and synovial IL-37 levels were significantly positively correlated with disease activity scores (r = 0.92, P
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