Pre-test Cortisol Levels in Predicting Short Synacthen Test Outcome: A Retrospective Analysis
| Autor: | Ravikumar Ravindran, Joanne L Carter, Asit Kumar, Florin Capatana, Ishrat N Khan, Mohamed A Adlan, Lakdasa D Premawardhana |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Clinical Medicine Insights: Endocrinology and Diabetes, Vol 15 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1179-5514 11795514 |
| DOI: | 10.1177/11795514221093316 |
| Popis: | Objective: Short Synacthen tests (SSTs) are expensive, dependent on Synacthen availability, and need supervision. To reduce SST testing, we examined the utility of pre-test cortisol (Cort0) and related parameters in predicting outcome. Design and Measurements: We retrospectively examined the following in all SSTs; (i) Cort0 (ii) indications (iii) and time and place of testing. Receiver operated characteristic (ROC) curves were devised for Cort0 to obtain the best cut-off for outcome prediction in those who had SSTs between 8 and 10 am (Group 1) and at other times (Group 2). Results: Of 506 SSTs, 13 were unsuitable for analysis. 111/493 SSTs (22.5%) were abnormal. (1) ROC curves predicted – (a) SST failure with 100% specificity when Cort0 was ⩽124 nmol/L (Group 1), or ⩽47 (Group 2); (b) a normal SST with 100% sensitivity when Cort0 ⩾314 nmol/L (Group 1) and ⩾323 nmol/L (Group 2). (2) There was significant correlation between Cort0 and 30-minute cortisol ( r s = 0.65-0.78, P |
| Databáze: | Directory of Open Access Journals |
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