COVID-19 Is Associated With a 4 Fold Increase in 30-day Mortality Risk in Hip Fracture Patients in the United Kingdom: A Systematic Review and Meta-analysis
| Autor: | Saleem Mastan MBChB, MRCS, MSc, Ghazal Hodhody MBChB, MRCS, MSc, Mohammed Sajid MBChB, MRCS, Rayaz Malik MBChB, PhD, Charalambos Panayiotou Charalambous BSc, MBChB, MSc, MD, FRCS(Tr&Orth) |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Geriatric Orthopaedic Surgery & Rehabilitation, Vol 13 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2151-4593 21514593 |
| DOI: | 10.1177/21514593221099375 |
| Popis: | Background Hip fracture in elderly patients is associated with a significant mortality which may be worsened by COVID-19 infection. Objective To undertake a systematic review and meta-analysis of studies assessing the effect of COVID-19 infection and mortality rates in hip fracture patients in the United Kingdom (UK) during the first surge of the pandemic. Design A systematic literature search of 9 online databases was undertaken independently by 2 reviewers using the Cochrane methodology for systematic reviews. Eligibility criteria were any study of an adult population with a hip fracture that assessed the relationship between COVID-19 infection and 30-day mortality in the UK. Meta-analysis was conducted using a random-effects model. Results Out of 309 identified articles, 10 studies reporting on 2448 hip fracture patients met the inclusion criteria. Meta-analysis showed that the estimated mortality rate in patients with laboratory confirmed COVID-19 infection was 32.5% (95% CI= 28.3 to 37.0) compared to 8.6% (95% CI= 6.3 to 11.6) in COVID-19 negative patients. Meta-analysis of 9 comparative studies showed a significantly higher mortality in patients with laboratory confirmed COVID-19 infection as compared to patients without (RR=3.937, 95% CI= 2.867 to 5.406, P |
| Databáze: | Directory of Open Access Journals |
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