| Autor: |
Giulia Rivasi, Matteo Bulgaresi, Enrico Mossello, Primo Buscemi, Chiara Lorini, Daniela Balzi, Riccardo Barucci, Ilaria Del Lungo, Salvatore Gangemi, Sante Giardini, Cecilia Piga, Eleonora Barghini, Serena Boni, Giulia Bulli, Paolo Carrai, Andrea Crociani, Antonio Faraone, Aldo Lo Forte, Letizia Martella, Simone Pupo, Giacomo Fortini, Irene Marozzi, Giulia Bandini, Claudia Cosma, Lorenzo Stacchini, Gabriele Vaccaro, Lorenzo Baggiani, Giancarlo Landini, Guglielmo Bonaccorsi, Andrea Ungar, Enrico Benvenuti |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Vaccines, Vol 9, Iss 10, p 1174 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines9101174 |
| Popis: |
Evidence on the effectiveness of SARS-CoV-2 vaccines in nursing home (NHs) residents is limited. We examined the impact of the BNT162b2 mRNA SARS-CoV-2 vaccine on the course of the epidemic in NHs in the Florence Health District, Italy, before and after vaccination. Moreover, we assessed survival and hospitalization by vaccination status in SARS-CoV-2-positive cases occurring during the post-vaccination period. We calculated the weekly infection rates during the pre-vaccination (1 October–26 December 2020) and post-vaccination period (27 December 2020–31 March 2021). Cox analysis was used to analyze survival by vaccination status. The study involved 3730 residents (mean age 84, 69% female). Weekly infection rates fluctuated during the pre-vaccination period (1.8%–6.5%) and dropped to zero during the post-vaccination period. Nine unvaccinated (UN), 56 partially vaccinated (PV) and 35 fully vaccinated (FV) residents tested SARS-CoV-2+ during the post-vaccination period. FV showed significantly lower hospitalization and mortality rates than PV and UV (hospitalization: FV 3%, PV 14%, UV 33%; mortality: FV 6%, PV 18%, UV 56%). The death risk was 84% and 96% lower in PV (HR 0.157, 95%CI 0.049–0.491) and FV (HR 0.037, 95%CI 0.006–0.223) versus UV. SARS-CoV-2 vaccination was followed by a marked decline in infection rates and was associated with lower morbidity and mortality among infected NH residents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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