Noninvasive Advanced Cardiovascular Magnetic Resonance–Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria

Autor: Jef Van den Eynde, Jos J. M. Westenberg, Mark G. Hazekamp, Hildo J. Lamb, Monique R. M. Jongbloed, Jolanda J. Wentzel, Sasa Kenjeres, Ilona A. Dekkers, Alexander Van De Bruaene, Friso M. Rijnberg, Arno A. W. Roest
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.123.033122
Popis: Background Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. Methods and Results A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular magnetic resonance assessment, including 4‐dimensional flow imaging and computational fluid dynamics. Estimated glomerular filtration rate (eGFR) 3 mg/mmol in 39.6%. The average eGFR decline rate was −1.83 mL/min per 1.73 m2 per year (95% CI, −2.67 to −0.99; P
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