Maternal supplementation with a synbiotic has distinct outcomes on offspring gut microbiota formation in A/J and C57BL/6 mice, differentially affecting airway inflammatory cell infiltration and mucus production

Autor: Claudio Fukumori, Mateus B. Casaro, Andrew M. Thomas, Eduardo Mendes, Willian R. Ribeiro, Amanda R. Crisma, Gilson M. Murata, Bruna Bizzarro, Emmanuel Dias-Neto, Joao C. Setubal, Maria A. Oliveira, Wothan Tavares-de-Lima, Rui Curi, Silvana Bordin, Patricia Sartorelli, Caroline M. Ferreira
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Functional Foods, Vol 61, Iss , Pp - (2019)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2019.103496
Popis: Emerging evidence has shown that the maternal diet influences the microbiota. Our objective was to elucidate whether synbiotic consumption during the perinatal period equally modulates offspring gut microbiota in the A/J and C57BL/6 and affects airway inflammatory cell infiltration. We administered the synbiotic to the dam throughout the whole perinatal period. To analyze the influence of gut microbiota changes on offspring health, we induced allergic airway inflammation on offspring. Twenty-four hours after the last ovalbumin challenge, pulmonary inflammation was analyzed. Perinatal synbiotic supplementation reduced eosinophilic inflammation and mucus production only in the C57BL/6 offspring. Synbiotic supplementation during the perinatal period increased the Lactobacillus genera, which could be associated with the immune regulatory effects observed in the C57BL/6 offspring. Interestingly, synbiotic supplementation increased the diversity of gut microbiota in the A/J offspring without improving airway inflammation, indicating that diversity itself was not sufficient to regulate experimental lung inflammation.
Databáze: Directory of Open Access Journals
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