| Autor: |
E. G. Ovsyannikova, K. D. Kaplanov, T. Yu. Klitochenko, A. V. Misyurin, I. L. Davydkin, L. V. Zaklyakova, E. A. Popov, B. N. Levitan |
| Jazyk: |
ruština |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Онкогематология, Vol 7, Iss 4, Pp 16-23 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1818-8346 |
| Popis: |
Mutation status of 36 chronic myeloid leukemia (CML) patients in chronic phase with primary and secondary imatinib resistance was analyzed. BCR-ABL mutations identified by direct DNA sequencing. BCR-ABL kinase domain mutations were detected in 30.5 % (11 of 36) of those patients. Most of identified mutations were missense mutations: Q252H, M244V, G250E, Y253F/H, E255K/V, T315I, M351T, F359V, F359C, F486S. Patients with BCR-ABL mutations have significantly lower 4-year event-free survival compared with CML patients without mutations (18 % vs. 53 %; р = 0.003). The results can be used as reference information in deciding on therapy in imatinib resistant CML patients with clinically relevant BCR-ABL mutations. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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