An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

Autor: Guo-Ming Zhao, Zhi-Bing Zheng, Dong-Mei Zhao, Xiao-Kui Wang, Guang-Qiang Xia, Xiu-Yan Yang, Song Li
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Molecules, Vol 18, Iss 9, Pp 11144-11152 (2013)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules180911144
Popis: An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Databáze: Directory of Open Access Journals