Clinical perspective and practices on pleural effusions in chronic systemic inflammatory diseases
| Autor: | Xuan Yao, Megat Abd Hamid, Anand Sundaralingam, Alice Evans, Roshan Karthikappallil, Tao Dong, Najib M. Rahman, Nikolaos I. Kanellakis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Breathe, Vol 16, Iss 4 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1810-6838 2073-4735 20734735 |
| DOI: | 10.1183/20734735.0203-2020 |
| Popis: | Systemic inflammatory diseases are a heterogeneous family of autoimmune chronic inflammatory disorders that affect multiple systems within the human body. Connective tissue disease (CTD) is a large group within this family characterised by immune-mediated inflammation of the connective tissue. This group of disorders are often associated with pleural manifestations. CTD-induced pleuritis exhibits a wide variety of symptoms and signs including exudative pleural effusions and chest pain. Accurate estimation of prevalence for CTD-related pleuritis is challenging as small effusions are asymptomatic and remain undetected. Rheumatoid arthritis and systemic lupus erythematosus are frequent CTDs and present with pleural pathology in approximately 5–20% and 17–60% of cases, respectively. By contrast, pleural involvement in systemic sclerosis, eosinophilia–myalgia syndrome, mixed connective tissue disease, ankylosing spondylitis, polymyositis and dermatomyositis syndrome is rare. Clinical management depends on the severity of symptoms; however, most effusions resolve spontaneously. In this review we discuss the pathophysiological mechanisms and the clinical considerations of CTD-induced pleuritis. |
| Databáze: | Directory of Open Access Journals |
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