| Autor: |
Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Chemistry Proceedings, Vol 8, Iss 1, p 94 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4583 |
| DOI: |
10.3390/ecsoc-25-11709 |
| Popis: |
In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA. The antioxidant effects of substituted 2-aminopyridine δ-lactone derivatives were evaluated through DPPH assay and revealed a great antioxidant capacity. The antifungal and antibacterial activities were investigated by disc diffusion method against clinical Gram-negative bacteria and against clinical fungi. The study shows moderate to very good antibacterial and antifungal activities for the new substituted 2-aminopyridine δ-lactone derivatives. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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