Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

Autor: Adeberg Sebastian, Bernhardt Denise, Harrabi Semi B., Nicolay Nils H., Hörner-Rieber Juliane, König Laila, Repka Michael, Mohr Angela, Abdollahi Amir, Weber Klaus-Josef, Debus Juergen, Rieken Stefan
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Radiology and Oncology, Vol 51, Iss 4, Pp 431-437 (2017)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.1515/raon-2017-0042
Popis: It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinical use the influence of metformin in glioblastoma is far from being understood especially in combination with other treatment modalities such as radiation and temozolomide.
Databáze: Directory of Open Access Journals