| Autor: |
Antti Hurme, Pinja Jalkanen, Jemna Heroum, Oona Liedes, Saimi Vara, Merit Melin, Johanna Teräsjärvi, Qiushui He, Sakari Pöysti, Arno Hänninen, Jarmo Oksi, Tytti Vuorinen, Anu Kantele, Paula A. Tähtinen, Lauri Ivaska, Laura Kakkola, Johanna Lempainen, Ilkka Julkunen |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.869990 |
| Popis: |
The emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made it more difficult to prevent the virus from spreading despite available vaccines. Reports of breakthrough infections and decreased capacity of antibodies to neutralize variants raise the question whether current vaccines can still protect against COVID-19 disease. We studied the dynamics and persistence of T cell responses using activation induced marker (AIM) assay and Th1 type cytokine production in peripheral blood mononuclear cells obtained from BNT162b2 COVID-19 mRNA vaccinated health care workers and COVID-19 patients. We demonstrate that equally high T cell responses following vaccination and infection persist at least for 6 months against Alpha, Beta, Gamma, and Delta variants despite the decline in antibody levels. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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