| Autor: |
Benoît S Assogba, Luc S Djogbénou, Jacques Saizonou, Pascal Milesi, Laurette Djossou, Innocent Djegbe, Welbeck A Oumbouke, Fabrice Chandre, Lamine Baba-Moussa, Mylene Weill, Michel Makoutodé |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Parasites & Vectors, Vol 7, Iss 1, Pp 1-9 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1756-3305 |
| DOI: |
10.1186/s13071-014-0548-9 |
| Popis: |
Abstract Background Malaria is endemic in sub-Saharan Africa with considerable burden for human health. Major insecticide resistance mechanisms such as kdr R and ace-1 R alleles constitute a hindrance to malaria vector control programs. Anopheles gambiae bearing both kdr and ace-1 resistant alleles are increasingly recorded in wild populations. In order to maintain the efficacy of vector control strategies, the characterization of concomitant kdr and ace-1 resistance, and their pleiotropic effects on malaria vector phenotype on insecticide efficacy are important. Methods Larval and adult bioassays were performed with different insecticide classes used in public health following WHO standard guidelines on four laboratory Anopheles gambiae strains, sharing the same genetic background but harboring distinct resistance status: KISUMU with no resistance allele; ACERKIS with ace-1 R allele; KISKDR with kdr R allele and ACERKDRKIS with both resistance alleles’ ace-1 R and kdr R . Results Larval bioassays indicate that the homozygote resistant strain harboring both alleles (ACERKDRKIS) displayed slightly but significantly higher resistance level to various insecticides like carbamates (bendiocarb, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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