| Autor: |
Richard eAng, Aaisha eOpel, Andrew eTinker |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Frontiers in Physiology, Vol 3 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2012.00096 |
| Popis: |
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels. A large number of RGSs can act as GAPs to inhibitory G-proteins and thus it is important to understand the network of RGSG-protein interaction. We will review our recent findings on in-vivo heart rate control in mice with global genetic deletion of various inhibitory G-protein alpha subunits. We will discuss potential central and peripheral contributions to the phenotype and the controversies in the literature. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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