A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids

Autor: Vsevolod V. Komissarov, Anatoly M. Kritzyn, Jouko J. Vepsäläinen
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 63 (2010)
Druh dokumentu: article
ISSN: 1860-5397
DOI: 10.3762/bjoc.6.63
Popis: A novel one-pot method was developed for the synthesis of the title compounds starting from 4-chloro-1-aryl-1-butanones 1, phosphorus trichloride and acetic acid. The end products 2 were obtained in 20–94% yield. The cyclization step under acidic conditions probably occurs as a result of anchimeric assistance of the phosphonic acid group.
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