| Autor: |
Christopher Darr, Pedro Fragoso Costa, Theresa Kahl, Alexandros Moraitis, Jenna Engel, Mulham Al-Nader, Henning Reis, Jens Köllermann, Claudia Kesch, Ulrich Krafft, Tobias Maurer, Daniel Köhler, Susanne Klutmann, Fabian Falkenbach, Jens Kleesiek, Wolfgang P. Fendler, Boris A. Hadaschik, Ken Herrmann |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
European Urology Open Science, Vol 54, Iss , Pp 28-32 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-1683 |
| DOI: |
10.1016/j.euros.2023.05.017 |
| Popis: |
In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging of radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent clinical prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) preoperatively on the day of surgery. Six patients received 68Ga-PSMA-11 and four 18F-PSMA-1007. Radioactivity of the resected specimen was measured again using a novel specimenPET/CT device (AURA10; XEOS Medical, Gent, Belgium) developed for intraoperative margin assessment. All index lesions of staging multiparametric magnetic resonance imaging could be visualized. Overall, specimenPET/CT correlated well with conventional PET/CT regarding detection of suspicious tracer foci (Pearson coefficient 0.935). In addition, specimenPET/CT demonstrated all lymph node metastases detected on conventional PET/CT (n = 3), as well as three previously undetected lymph node metastases. Importantly, all positive or close ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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