| Autor: |
Fabrizia D'Antonio, Suzanne Reeves, Yucheng Sheng, Emma McLachlan, Carlo deLena, Robert Howard, Julie Bertrand |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 308-315 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2163-8306 |
| DOI: |
10.1002/psp4.12389 |
| Popis: |
The presence of psychosis is associated with a more rapid decline in Alzheimer's disease (AD), but the impact of paranoid (persecutory delusions) and misidentification (misperceptions and/or hallucinations) subtypes of psychosis on the speed of decline in AD is still unclear. We analyzed data on Alzheimer's Disease Neuroimaging Initiative 2 participants with late mild cognitive impairment or AD, and we described individual trajectories of Alzheimer's Disease Assessment Scale–Cognitive Subscale scores using a semimechanistic logistic model with a mixed effects–based approach, which accounted for dropout and adjusted for baseline Mini Mental State Examination scores. The covariate model included psychosis subtypes, age, gender, education, medications, and Apolipoprotein E epsilon 4 (Apo‐e ε4 genotype). We found that the Alzheimer's Disease Assessment Scale–Cognitive Subscale rate of increase was doubled in misidentification (βr,misid_subtype = 0.63, P = 0.031) and mixed (both subtypes; βr,mixed_subtype = 0.70, P = 0.003) when compared with nonpsychotic (or paranoid) patients, suggesting that the misidentification subtype may represent a distinct AD sub‐phenotype associated with an accelerated pathological process. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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