Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

Autor: Yi-Fan Chen, Frank Luh, Yuan-Soon Ho, Yun Yen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)
Druh dokumentu: article
ISSN: 1423-0127
DOI: 10.1186/s12929-024-01055-0
Popis: Abstract Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.
Databáze: Directory of Open Access Journals
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