Blueberry-enriched diet protects rat heart from ischemic damage.

Autor: Ismayil Ahmet, Edward Spangler, Barbara Shukitt-Hale, Magdalena Juhaszova, Steven J Sollott, James A Joseph, Donald K Ingram, Mark Talan
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: PLoS ONE, Vol 4, Iss 6, p e5954 (2009)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0005954
Popis: OBJECTIVES:to assess the cardioprotective properties of a blueberry enriched diet (BD). BACKGROUND:Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. METHODS AND RESULTS:Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (t(MPT)) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (p
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