Comparative efficacy of leukotriene modifier and inhaled corticosteroids in the complex treatment of steroid-naive patients with bronchial asthma combined with chronic obstructive pulmonary disease with neutrophilic type of inflammation
| Autor: | Yu. I. Feshchenko, L. O. Yashyna, V. I. Ihnatieva, M. O. Polianska, S. H. Opimakh, I. V. Zvol, S. M. Moskalenko, H. L. Humeniuk, N. A. Vlasova, L. A. Halai |
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| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Zaporožskij Medicinskij Žurnal, Vol 23, Iss 4, Pp 516-523 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2310-1210 2306-4145 |
| DOI: | 10.14739/2310-1210.2021.4.229508 |
| Popis: | The aim: to compare the efficacy and tolerability of the leukotriene modifier and inhaled corticosteroids in combination with long-acting β2-agonist formoterol in steroid-naive patients with asthma combined with COPD with neutrophilic inflammation. Materials and methods. After obtaining the written consent, 30 patients with asthma combined with COPD and a number of blood neutrophils >4000/μl were randomized (1:1): group I – received a fixed combination of budesonide/formoterol 160/4.5 μg/1 inhalation twice daily as a basic therapy; group II – montelukast 1 tab. (10 mg) once daily and inhalation of formoterol 12 mcg/dose twice daily. The duration of therapy was 12 weeks. General clinical methods, asthma control questionnaires, COPD questionnaire, physical tolerance evaluation (6-minute walk test), pulmonary function tests, quality of life assessment were performed to all the patients before and after the treatment course studied. Results. The combination of budesonide/formoterol improved clinical symptoms – significantly (P |
| Databáze: | Directory of Open Access Journals |
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