| Autor: |
E Burki, J Logel, M Sinensky |
| Jazyk: |
angličtina |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 28, Iss 10, Pp 1199-1205 (1987) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)38609-0 |
| Popis: |
It has been proposed that an endogenously synthesized oxysterol mediates the regulation of cholesterol biosynthesis by low density lipoprotein in cultured mammalian cells. Studies in this report demonstrate that under conditions in which squalene conversion to sterols is blocked either by inhibition of squalene cyclization or lanosterol demethylation, or both, low density lipoprotein regulates 3-hydroxy-3-methylglutaryl coenzyme A reductase normally. These observations rule out the hypotheses that either an endogenously synthesized oxygenated cholesterol biosynthetic intermediate or epoxysterol is required to mediate the inhibition of this enzyme by low density lipoprotein. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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