Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not

Autor:	Anika Frank, Jonas Bendig, Iñaki Schniewind, Witold H. Polanski, Stephan B. Sobottka, Heinz Reichmann, Katja Akgün, Tjalf Ziemssen, Lisa Klingelhoefer, Björn H. Falkenburger
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-022-05117-x
Popis:	Abstract Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c89caf365ecf45e391c573c669ccd009 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.