Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol
| Autor: | Aline Sayuri Lima Iida, Karina Novais Luz, Taís Téo Barros-Alexandrino, Carmen Sílvia Fávaro-Trindade, Samantha Cristina de Pinho, Odílio Benedito Garrido Assis, Milena Martelli-Tosi |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Polímeros, Vol 29, Iss 4 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1678-5169 0104-1428 |
| DOI: | 10.1590/0104-1428.04119 |
| Popis: | Abstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy. |
| Databáze: | Directory of Open Access Journals |
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