Desmin’s conformational modulation by hydrophobicity

Autor: Kural Mangıt Ecem, Cevheroğlu Orkun, Dinçer Pervin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Türk Biyokimya Dergisi, Vol 49, Iss 2, Pp 236-243 (2024)
Druh dokumentu: article
ISSN: 1303-829X
DOI: 10.1515/tjb-2023-0220
Popis: Nucleocytoplasmic transport is one of the key features in regulation of cellular physiology. Developing a better understanding of the molecular mechanism underlying the nucleocytoplasmic shuttling of proteins can broaden our perspective and understanding on the elaborate sorting mechanisms within cells. Desmin is a muscle specific intermediate filament with amphiphilic properties and has interactions with the components of the nuclear pore complex which facilitates the transport between the cytoplasm and nucleus. The study aims to develop a better understanding of the amphiphilic nature of desmin and its relation to nucleocytoplasmic transport.
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