Amyloid beta is associated with carotid wall echolucency and atherosclerotic plaque composition

Autor: Dimitrios Delialis, Georgios Georgiopoulos, Simon Tual-Chalot, Lasthenis Angelidakis, Evmorfia Aivalioti, Georgios Mavraganis, Kateryna Sopova, Antonios Argyris, Peggy Kostakou, Christina Konstantaki, Maria Papaioannou, Diamantis Tsilimigras, Konstantinos Chatoupis, Achilleas A. Zacharoulis, George Galyfos, Fragiska Sigala, Konstantinos Stellos, Kimon Stamatelopoulos
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-64906-8
Popis: Abstract Circulating amyloid-beta 1–40 (Αb40) has pro-atherogenic properties and could serve as a biomarker in atherosclerotic cardiovascular disease (ASCVD). However, the association of Ab40 levels with morphological characteristics reflecting atherosclerotic plaque echolucency and composition is not available. Carotid atherosclerosis was assessed in consecutively recruited individuals without ASCVD (n = 342) by ultrasonography. The primary endpoint was grey scale median (GSM) of intima-media complex (IMC) and plaques, analysed using dedicated software. Vascular markers were assessed at two time-points (median follow-up 35.5 months). In n = 56 patients undergoing carotid endarterectomy, histological plaque features were analysed. Plasma Αb40 levels were measured at baseline. Ab40 was associated with lower IMC GSM and plaque GSM and higher plaque area at baseline after multivariable adjustment. Increased Ab40 levels were also longitudinally associated with decreasing or persistently low IMC and plaque GSM after multivariable adjustment (p
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