Multicenter, prospective, observational study for urinary exosomal biomarkers of kidney allograft fibrosis

Autor: Mi Joung Kim, Hye Eun Kwon, Hye-Won Jang, Jin-Myung Kim, Jae Jun Lee, Joo Hee Jung, Youngmin Ko, Hyunwook Kwon, Young Hoon Kim, Heungman Jun, Sang Jun Park, Jun Gyo Gwon, Sung Shin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-71279-5
Popis: Abstract Severity of deceased donor kidney fibrosis impacts graft survival in deceased-donor kidney transplantation. Our aim was to identify potential miRNA biomarkers in urinary exosomes that mirror interstitial fibrosis and tubular atrophy (IFTA) severity. Among 109 urine samples from deceased donors, 34 displayed no IFTA in the zero-day biopsy (No IFTA group), while the remaining 75 deceased donor kidneys exhibited an IFTA score ≥ 1 (IFTA group). After analyzing previous reports and electronic databases, six miRNAs (miR-19, miR-21, miR-29c, miR-150, miR-200b, and miR-205) were selected as potential IFTA biomarker candidates. MiR-21, miR-29c, miR-150, and miR-205 levels were significantly higher, while miR-19 expression was significantly lower in the IFTA group. MiR-21 (AUC = 0.762; P
Databáze: Directory of Open Access Journals
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