Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate

Autor: Waseem Hussain Raja, Fayaz Ahmad Zargar, Naseer Ahmad Baba, Parveez Ahmad Para, Mudasir Sultana, Hina Ashraf Waiz, Nisar Ahmad Nisar
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Veterinary World, Vol 6, Iss 8, Pp 461-466 (2013)
Druh dokumentu: article
ISSN: 0972-8988
2231-0916
DOI: 10.5455/vetworld.2013.461-466
Popis: Aim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received th chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IV th received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group V received th vitamin C @ 100mg/kg in water, group VI received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ th th 100mg/kg , group VII received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIII received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead. [Vet World 2013; 6(8.000): 461-466]
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