Unforeseen complications of pembrolizumab in breast reconstruction post-mastectomy

Autor: Murad Aldarayseh, Sohail Singh Sodhi, Gamal Musleh, Dyuti Kumar, Michelle Cholankeril
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: European Journal of Case Reports in Internal Medicine (2024)
Druh dokumentu: article
ISSN: 2284-2594
DOI: 10.12890/2024_004675
Popis: A 53-year-old post-menopausal Indian female presented with invasive ductal carcinoma, treated with neoadjuvant chemotherapy and pembrolizumab due to a PD-L1 combined positive score of 5. Following a right mastectomy and axillary dissection, she received a breast expander and AlloDerm™ graft. After resuming pembrolizumab and paclitaxel postoperatively, she developed severe breast redness and high-grade fever, necessitating expander removal due to suspected pembrolizumab-induced complications. This case underscores the unique and severe adverse effects of pembrolizumab on breast reconstruction, highlighting the need for careful monitoring and management in patients undergoing similar treatments.
Databáze: Directory of Open Access Journals