Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription

Autor:	Shiyou Wei, Dandan Ling, Jingui Zhong, Rui Chang, Xinyu Ling, Zhigang Chen, Ruowang Duan
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Elk1 Fcgr2b ARDS ALI Inflammatory cell infiltration Therapeutics. Pharmacology RM1-950 Biochemistry QD415-436
Zdroj:	Molecular Medicine, Vol 30, Iss 1, Pp 1-14 (2024)
Druh dokumentu:	article
ISSN:	1528-3658
DOI:	10.1186/s10020-024-00820-z
Popis:	Highlights LPS-induced ARDS rats and PMVECs have low Fcgr2b level and high Elk1 level; Fcgr2b overexpression mitigates LPS-induced ALI/ARDS in rats and PMVECs; Elk1 knockdown mitigates LPS-induced ALI/ARDS in rats and PMVECs; Elk1 represses Fcgr2b transcription by recruiting H3K9me3; Elk1/Fcgr2b axis aggravates LPS-induced ALI/ARDS in rats and PMVECs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/897b52d54fb24626a6da7319e0be53a9 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ