| Autor: |
Wen‐Qiong Xue, Yong‐Qiao He, Xiao‐Yu Liao, Fang‐Fang Li, Ya‐Fei Xu, Feng‐Hua Xu, Xi‐Zhao Li, Qi‐Sheng Feng, Li‐Zhen Chen, Su‐Mei Cao, Qing Liu, Yi‐Xin Zeng, Wei‐Hua Jia |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Cancer Medicine, Vol 7, Iss 7, Pp 3453-3464 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.1597 |
| Popis: |
Abstract The link of nasopharyngeal carcinoma (NPC) with Epstein‐Barr virus (EBV) has been established for decades. Although an abnormal high level of EBV sero‐antibody spectrum and cell‐free circulating EBV DNA loads were exhibited in NPC patients, oral EBV DNA loads, which are primarily responsible for the EBV transmission, has not been previously studied in NPC patients. We conducted an epidemiological study to measure the oral EBV loads, viral components, and the relationship with the serum antibody titers in a large case‐control population (968 cases and 1656 controls) and a family‐based population (91 cases and 165 unaffected family members). EBV DNA loads were detected by quantitative PCR approach targeting the BamHI‐W region. Although a large individualized variation existed, we still observed a decreased oral EBV DNA loads in the population of NPC patients compared to that of healthy controls (ORs were 1.00, 0.69, 0.62, 0.33 classified by the quartiles of viral loads, Ptrend |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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