| Autor: |
Sonal Sogani, Vandana Varma, Purnima Dey Sarkar |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Al Ameen Journal of Medical Sciences, Vol 08, Iss 04, Pp 266-270 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
0974-1143 |
| Popis: |
Background: During normal pregnancy, changes in thyroid function are very well documented and these changes are physiological and have been considered as one of the pathophysiological causes of preeclampsia. The information regarding thyroid function in preeclampsia is scanty. Aim: To estimate the levels of thyroid hormones in preeclamptic pregnant women and to compare it with healthy normotensive pregnant women. Material and methods: Thirty five (35) pregnant women clinically diagnosed as preeclampsia were taken as subjects and an equal number of age matched, parity matched and gestation age matched healthy normotensive pregnant women were taken as controls for the study. This is the case-control hospital based study carried in the Department of Biochemistry M.G.M. Medical College and associated M.Y. Hospital. Indore (M.P.) Blood samples collected were estimated for T3, T4 and TSH by a one step enzyme immunoassay sandwich method with a final fluorescent detection (ELFA). Comparison between both the groups was done by Student’s t-test. Results: There were no significant differences between the two groups in age and body mass index (BMI) but significantly higher differences in gestational age, systolic and diastolic blood pressure was observed. When the levels of T3 and T4 were compared between healthy normotensive pregnant and preeclamptic pregnant women, no significant difference was observed between both the groups. The study shows highly significant increase in the TSH levels in preeclampsia as compared to normal pregnancy. Conclusion: The study concluded that the thyroid disorder is one of the predisposing causes for preeclampsia. Hence thyroid hormonal assay can be considered as a screening test for early diagnosis and treatment of preeclampsia to prevent further complications of it. |
| Databáze: |
Directory of Open Access Journals |
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