Using PVC ion-selective electrodes for the potentiometric flow injection analysis of distigmine in its pharmaceutical formulation and biological fluids
| Autor: | Yousry M. Issa, Amal F. Khorshid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Journal of Advanced Research, Vol 2, Iss 1, Pp 25-34 (2011) |
| Druh dokumentu: | article |
| ISSN: | 2090-1232 2090-1224 |
| DOI: | 10.1016/j.jare.2010.08.007 |
| Popis: | The construction and electrochemical response characteristics of poly(vinylchloride) (PVC) membrane selective electrodes for the determination of distigmine (Ds) are described. The sensing membrane comprised an ion-pair based on distigmine phosphomolybdate (Ds-PM), distigmine phosphotungstate (Ds-PT), distigmine silicomolybdate (Ds-SM), distigmine silicotungstate (Ds-ST), distigmine tetraphenylborate (Ds-TPB), and distigmine reineckate (Ds-Rein) in a plasticized PVC matrix with dioctylphthalate (DOP). The influence of membrane composition on the electrodes’ response was studied. The electrodes showed a fast, stable and Nernstian response over a wide distigmine concentration range 5.0 × 10−7–1 × 10−2 mol L−1 with a slope of ∼30.5 ± 1.0 mV dec−1. The response is independent of the pH of test solution within the range 3.8–10.5. The life span of the electrodes extends to at least 2 months without any considerable divergence in potential and has a fast response time of |
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