Successful treatment with dupilumab for mucus plugs in severe asthma

Autor:	Moriyasu Anai, Chieko Yoshida, Hiroki Izumi, Kei Muramoto, Koichi Saruwatari, Yusuke Tomita, Hidenori Ichiyasu, Takuro Sakagami
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	dupilumab mucus plugs severe asthma Diseases of the respiratory system RC705-779
Zdroj:	Respirology Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2051-3380
DOI:	10.1002/rcr2.1074
Popis:	Abstract A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.
Databáze:	Directory of Open Access Journals
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