Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer

Autor: Xiaoli Cao, Juan Yao, Meiqun Jia, Xianjuan Shen, Jinye Zhang, Shaoqing Ju
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1757-2215
DOI: 10.1186/s13048-022-00950-0
Popis: Abstract Growing evidence indicates that lncRNA colon cancer-associated transcript 2 (CCAT2) is associated with cancers. However, the clinical value of CCAT2 in cervical cancer (CC) remains unclear. In this study, serum CCAT2 level was detected by real-time quantitative PCR (RT-qPCR). Carbohydrate antigen 125 (CA125) and squamous-cell carcinoma antigen (SCC) were detected by electrochemiluminescence. A receiver operating characteristic (ROC) curve was utilized to estimate the diagnostic efficiency of CCAT2. Kaplan-Meier survival analysis and univariable and multivariable analyses were performed to assess the prognostic value of CCAT2. The relative expression level of CCAT2 in primary CC patients was significantly higher than that in cervical intraepithelial neoplasias (CIN) patients and healthy controls (both P
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