Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture

Autor: Samira Radmand, Homa Rezaei, Hongkun Zhao, Elaheh Rahimpour, Abolghasem Jouyban
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Chemistry, Vol 17, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 2661-801X
DOI: 10.1186/s13065-023-00950-1
Popis: Abstract This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and density of deferiprone in non-aqueous mixtures of propylene glycol and ethanol were measured in the temperatures 293.2–313.2 K. Some equations including van’t Hoff, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, the mixture response surface and modified Wilson equations were used for the mathematical data modeling. The apparent thermodynamic parameters of the deferiprone dissolution process were computed and reported.
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