Nitric oxide synthase and its function in animal reproduction: an update

Autor: Wei Zhang, Su juan Chen, Li ya Guo, Zijing Zhang, Jia bin Zhang, Xiao meng Wang, Xiang bo Meng, Min ying Zhang, Ke ke Zhang, Lin lin Chen, Yi wei Li, Yuliang Wen, Lei Wang, Jian he Hu, Yue yu Bai, Xiao jian Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Physiology, Vol 14 (2023)
Druh dokumentu: article
ISSN: 1664-042X
DOI: 10.3389/fphys.2023.1288669
Popis: Nitric oxide (NO), a free radical labile gas, is involved in the regulation of various biological functions and physiological processes during animal reproduction. Recently, increasing evidence suggests that the biological role and chemical fate of NO is dependent on dynamic regulation of its biosynthetic enzyme, three distinct nitric oxide synthase (NOS) according to their structure, location and function. The impact of NOS isoforms on reproductive functions need to be timely elucidated. Here, we focus on and the basic background and latest studies on the development, structure, importance inhibitor, location pattern, complex functions. Moreover, we summarize the exactly mechanisms which involved some cell signal pathways in the regulation of NOS with cellular and molecular level in the animal reproduction. Therefore, this growing research area provides the new insight into the important role of NOS male and female reproduction system. It also provides the treatment evidence on targeting NOS of reproductive regulation and diseases.
Databáze: Directory of Open Access Journals