| Autor: |
Ye Liu, Sicheng Li, Jinjian Huang, Ze Li, Kang Chen, Guiwen Qu, Xiuwen Wu, Jianan Ren |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Animal Models and Experimental Medicine, Vol 7, Iss 4, Pp 562-569 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2576-2095 |
| DOI: |
10.1002/ame2.12376 |
| Popis: |
Abstract Introduction This study aimed to establish an animal model of open abdomen (OA) through temporary abdominal closure via different techniques. Methods Adult male Sprague–Dawley rats were randomly divided into three groups: group A (OA with polypropylene mesh alone); group B (OA with polypropylene mesh combined with a patch); and group C (OA with polypropylene mesh and a sutured patch). Vital signs, pathophysiological changes, and survival rates were closely monitored in the rats for 7 days after surgery. Abdominal X‐rays and histopathological examinations were performed to assess abdominal organ changes and wound healing. Results The results showed no significant difference in mortality rates among the three groups (p > 0.05). However, rats in group B exhibited superior overall condition, cleaner wounds, and a higher rate of wound healing compared to the other groups (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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