| Autor: |
Andrew McDavid, Nathan Laniewski, Alex Grier, Ann L. Gill, Haeja A. Kessler, Heidie Huyck, Elizabeth Carbonell, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Jennifer Carnahan, Andrew M. Dylag, David J. Topham, Ann R. Falsey, Mary T. Caserta, Gloria S. Pryhuber, Steven R. Gill, Kristin M. Scheible |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
iScience, Vol 25, Iss 4, Pp 104007- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.104007 |
| Popis: |
Summary: Neonatal immune-microbiota co-development is poorly understood, yet age-appropriate recognition of – and response to – pathogens and commensal microbiota is critical to health. In this longitudinal study of 148 preterm and 119 full-term infants from birth through one year of age, we found that postmenstrual age or weeks from conception is a central factor influencing T cell and mucosal microbiota development. Numerous features of the T cell and microbiota functional development remain unexplained; however, by either age metric and are instead shaped by discrete perinatal and postnatal events. Most strikingly, we establish that prenatal antibiotics or infection disrupt the normal T cell population developmental trajectory, influencing subsequent respiratory microbial colonization and predicting respiratory morbidity. In this way, early exposures predict the postnatal immune-microbiota axis trajectory, placing infants at later risk for respiratory morbidity in early childhood. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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