| Autor: |
Sofia Roth, Emilio Flint, Lea Ghataore, Vishal C. Patel, Arjuna Singanayagam, Royce P. Vincent, Evangelos Triantafyllou, Yun Ma, William Bernal, Georg Auzinger, Michael Heneghan, Charalambos Antoniades, Mirjam Christ-Crain, Mark J.W. McPhail, David R. Taylor, Julia Wendon, Christine Bernsmeier |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Gastro Hep Advances, Vol 2, Iss 1, Pp 72-82 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2772-5723 |
| DOI: |
10.1016/j.gastha.2022.08.006 |
| Popis: |
Background and Aims: The clinical, prognostic, and therapeutic impact of adrenal insufficiency in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) remains controversial and exact diagnostic criteria are lacking. We sought to determine the diagnostic and therapeutic value of cortisol measurement and glucocorticoid (GC) treatment in ALF and ACLF. Methods: 28-day transplant-free survival (TFS) was studied in relation to absolute cortisol concentrations and to GC treatment in ALF (n = 30) and ACLF (n = 34) patients. Cortisol concentrations and short synacthen test were assessed by chemiluminescence immunoassay and liquid chromatography-mass spectrometry. Clinicians decided independently on GC treatment. In relation, phenotypic and functional characteristics of circulating monocytes were assessed. Results: In ALF, baseline cortisol concentrations |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
