TGF-β downregulation-induced cancer cell death is finely regulated by the SAPK signaling cascade

Autor: Zhezhu Han, Dongxu Kang, Yeonsoo Joo, Jihyun Lee, Geun-Hyeok Oh, Soojin Choi, Suwan Ko, Suyeon Je, Hye Jin Choi, Jae J. Song
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-018-0189-8
Popis: Cancer: Tipping the signaling balance Reducing the levels of the multifunctional protein transforming growth factor (TGF)-β in cancer cells prevents tumor growth in mice. Previous studies have shown that high levels of TGF-β in cancerous tissue are associated with accelerated disease progression. Hye Jin Choi and Jae J Song at Yonsei University in Seoul, South Korea, and colleagues infected cancer cells with genetically modified viruses that reduced the expression of the gene encoding TGF-β. The resulting decrease in TGF-β protein led to cell death by stimulating the production of reactive oxygen species and signaling through the apoptosis signal-regulating kinase 1 (ASK1) pathway. When tumor-bearing mice were infected with these modified viruses, their overall survival was improved. Further understanding the mechanisms through which TGF-β regulates cancer cell survival will contribute to the development of new approaches in cancer treatment.
Databáze: Directory of Open Access Journals
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