Changes in urine microalbumin-to-creatinine ratio in children with sickle cell disease over time

Autor: Ibrahim F. Shatat, Suparna Qanungo, Shannon Hudson, Marilyn M. Laken, Susan M Hailpern
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 4 (2016)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2016.00106
Popis: Background: Approximately 20% of children with sickle cell disease (SCD) have microalbuminuria (MA). Very little is known about the progression of MA in children and young adults with SCD. Methods: In this study, we analyzed 5 year EMR data of 373 children (with ≥2 Microalbumin to creatinine (MA/Cr) ratio measurements) followed at the Medical University of South Carolina to determine the rate, direction, magnitude and predictors of MA/Cr change over time. Results: Age range was 1 – 22 years; mean 10.2 ± 5.2 years, 49.5% were male. Median follow up duration was 3.12 ±1.16 years. At baseline, 328 children had normal (
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