The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer
| Autor: | Nurija Bilalović, Semir Vranić, Senad Hasanagić, Hiba Basić, Aida Tatarević, Semir Bešlija, Ivan Selak |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Biomolecules & Biomedicine, Vol 4, Iss 4 (2004) |
| Druh dokumentu: | article |
| ISSN: | 2831-0896 2831-090X |
| DOI: | 10.17305/bjbms.2004.3352 |
| Popis: | Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the expression patterns of Bcl-2, estrogen receptors (ER), progesterone receptors (PR) in 71 primary invasive breast carcinomas and their association with other clinicopathological parameters. Samples from 71 patients with invasive breast cancer with follow-up ranging from 4-103 months (median 57 months) were included in the study. Forty-six patients (66%) obtained a complete response, while 5 (9%) were considered non-responders during the follow up period of 103 months. Eighteen (25%) patients died, 15 (21%) from primary disease and 3 (4%) from other disease. In unvaried analysis, tumor size ( |
| Databáze: | Directory of Open Access Journals |
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