Knockdown of LMNA inhibits Akt/β-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells
| Autor: | Hui Xin, Yu Tang, Yan-Hong Jin, Hu-Li Li, Yu Tian, Cong Yu, Ze-Ju Zhao, Ming-Song Wu, You-Fu Pan |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Cell Adhesion & Migration, Vol 17, Iss 1, Pp 1-14 (2023) |
| Druh dokumentu: | article |
| ISSN: | 19336918 1933-6926 1933-6918 |
| DOI: | 10.1080/19336918.2023.2260644 |
| Popis: | ABSTRACTThe LMNA gene encoding lamin A/C is amplified in some clear cell renal cell carcinoma (ccRCC) samples. Our data showed that depletion of the tumor suppressor PBRM1 can upregulate lamin A/C levels, and lamin A/C could interact with PBRM1. However, the role of lamin A/C in ccRCC is not yet fully understood. Our functional assays showed that although the proliferation ability was slightly impaired after LMNA depletion, the migration and invasion of ccRCC cells were significantly inhibited. This suppression was accompanied by a reduction in MMP2, MMP9, AKT/p-AKT, and Wnt/β-catenin protein levels. Our data therefore suggest that lamin A/C, as an interaction partner of the tumor suppressor PBRM1, plays a crucial role in tumor invasion and metastasis in ccRCC. |
| Databáze: | Directory of Open Access Journals |
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