Association between miR-138-5p, miR-132-3p, SIRT1, STAT3, and CD36 and atherogenic indices in blood mononuclear cells from patients with atherosclerosis

Autor: Samira Ehsani, Maysam Mard‑Soltani, Fatemeh Ahmadpour, Gholamreza Shahsavari
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2090-2441
DOI: 10.1186/s43042-023-00464-4
Popis: Abstract Backgrounds Developed countries have a high mortality rate from atherosclerosis and are frequently linked to inflammation and other blood lipid disorders. MicroRNA expression can affect atherosclerotic plaque formation, lipid metabolism, inflammation, and other related processes. The search aimed to determine whether microRNA-138-5p or microRNA-132-3p expression levels are related to patient atherogenic genes. Methods Angiographic diagnostic method was used to select 45 healthy samples and 45 atherosclerosis patients, along with the laboratory and demographic information. After isolating peripheral blood mononuclear cells (PBMCs) from blood, the levels of miR-138 and miR-132 and the relative expression of Sirtuin 1 (SIRT1), signal transducer and activator of transcription-3 (STAT3), and CD36 genes measured using real-time PCR. Results miR-138 was upregulated compared to the control group in the atherosclerosis patient group (P
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